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1. 基本信息
品系名称：B6-Tigitem1(hTigit)Vst/Vst
常用名：C57BL/6-Tigit人源化必威; Tigit人源化必威;Hu-Tigit
背景：C57BL/6NCrl
毛色：黑色
品系建立：
采用CRISPR-Cas9辅助的方法，将必威Tigit基因(T Cell Immunoreceptor With Ig And ITIM Domains)替换为人源Tigit。这样在Tigit人源化必威体内，使用人源Tigit抗体抑制剂时就可以识别，进行相关的药效或药物筛选实验。
2. 应用领域
-人源化和癌症治疗
-免疫治疗
-药物筛选
3. 参考文献
（1）The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL.Nat Immunol. 2009 Jan;10(1):48-57. doi: 10.1038/ni.1674. Epub 2008 Nov 16.
（2）Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL.Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5399-404. doi: 10.1073/pnas.1120606109. Epub 2012 Mar 15.
